97th DOG Annual Meeting 1999

K94

CREUTZFELD-JAKOB DISEASE: A PROBLEM FOR CORNEAL TRANSPLANTATION

T. Bredehorn, F. Wilhelm, C. Wiederhold, G. I. W. Duncker

Creutzfeld-Jakob disease (CJD) belongs to the group of human transmissible spongiform subacute encephalopathies (TSSE) and is an always fatal degenerative illness of the central nervous system. Males and females are affected in approximately equal numbers and classically it presents in patients between 50 and 75 years of age. The prevalence of CJD is 1 case per million head of population. CJD occurs in a familial and sporadic form, moreover in less than 5% CJD occurs after iatrogenic transmission. Up to now corneal transplantation was clearly implicated as the origin of CJD in 3 cases. The aim of this study is to check possible risks factors and exclusion criteria of CJD for corneal transplantation.

Methods: 2415 potential cornea donors at the University Hospital of Halle were investigated for possible risk factors of CJD.

Results: One patient deceased on CJD, no organ or tissue was donated. 28 potential donors were identified to be in the higher risk group of CJD, also no organs of tissues were harvested. In conclusion it is strongly recommended that patients belonging to the risk group of CJD, patients deceased on central nervous system diseases of unknown origin and etiology and patient that died in psychiatric clinics be excluded from organ and tissue donation.

University Eye Clinic of Halle-Wittenberg, Magdeburger Str. 8, D-06097 Halle


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