97th DOG Annual Meeting 1999
MULTIFOCAL ELECTRORETINOGRAPHY IN AGE RELATED MACULAR DEGENERATION - CHANGES IN AMPLITUDE OF THE FIRST ORDER KERNEL
B. Jurklies, M. Weismann
Methods: Based on the findings of fluorescein angiography, 55 Patients with exudative ARMD were divided into three groups: Group I (n=12) had classic, group II (n=37) had occult, and group III (n=6) had both classic and occult choroidal neovascularization (CNV). Using a pseudorandom m-sequence, 103 locations within the central 30º were stimulated (maximal luminance of 200 cd/sqm and 300 cd/sqm) concurrently using the VERIS-System (EDI, San Francisco). The response components were extracted for each stimulated retinal location. Mean amplitudes (1st order kernel) of ring 1 (center) to 6 (periphery) with different eccentricity were evaluated and compared to a normal control group. Normalized amplitudes were compared to each other for each group.
Results: Amplitudes were reduced in all of three AMD groups compared to the normal control group. The changes were most evident in the central stimulated fields of 7.5º (ring 1-3) corresponding to the site of CNV. However, a moderate reduction in amplitude was recorded in the periphery of the stimulated retinal field. Normalized amplitudes of the central rings were more reduced in group III than in group I, while group II was less severely affected. The amplitudes were affected under both luminance conditions. The reduction was slightly more evident with the luminance of lower intensity.
Conclusions: Amplitudes (1st order kernel) were affected depending on the eccentricity and localization. In addition, they were affected depending on the type of CNV and may, at least in part, correlate with the activity of CNV.
Universitäts-Augenklinik, Hufelandstraße 55, 45122 Essen, Germany
Supported by Deutsche Forschungsgemeinschaft (DFG), grant Ju 1-1