97th DOG Annual Meeting 1999
NONSTEROIDAL ANTIINFLAMMATORY DRUGS FOR TREATING PAIN AFTER PHOTOTHERAPEUTIC KERATECTOMY
M. Kohlhaas, J. Carstens, A. Walter
After PTK of recurrent corneal erosions patients often complain of severe pain. In this prospective and randomized clinical trial the influence of nonsteroidal antiinflammatory drugs on the postoperative pain was examined.
Method: 40 patients with recurrent corneal erosions were treated with PTK. Each patient was treated postoperatively with Floxal and Vitamin A ointment 6x daily. 4 groups, each of 10 patients, were randomized and treated additionally with Keterolac-Trometazol (group 1), Diclofenac (group 2), Flurbiprofen (group 3) and Polyvinylalcohol (group 4). The postoperative pain was measured 3 times a day with a painscore between 0 and 10 (no pain to extrem severe pain).
Results: There was no significant difference in healing time of the 4 groups. However, psychometric analysis showed a significant (p<0,01) decrease in pain in group 1 and 2 (1,9 and 2,4) comparing to group 3 and 4 (3,5 and 4,4).
Conclusion: Addition of a nonsteroidal antiinflammatory drug, in particular Keterolac-Trometazol, to a treatment regimen significantly decreases the pain after PTK.
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