97th DOG Annual Meeting 1999
THE SIZE OF CHOROIDAL NEOVASCULARISATION (CNV) AS AN IMPORTANT PARAMETER FOR RADIOTHERAPY IN AGE-RELATED MACULAR DEGENERATION
1A. Pacurar, 2A. Röser, 2R. B. Schilcher, 1E. Gerke
Numerous studies on the effect of radiotherapy in CNV showed only limited success. Analysing th results of our study, however, we noticed, that the outcome of a radiotherapy correlates to the size of the CNV.
Patients and Methods: Only patients with subfoveolar CNV in the early stage of AMD and a visual acuity of at least 20/100 were treated. The other eye already had suffered from visual loss due to subretinal fibrosis. 25 patients met the above mentioned criteria. The radiotherapy was performed with 8x2 Gy at an linear accelerator with 18 MV over a 40º laterally to the longitudinal axis of the patient tilted field of 3,5x2,2 cm size. Follow up visits were at 12, 26 and 52 weeks after radiation.
Results: Looking at the course of visual acuity in all treated eyes one year after radiation the results show a great variety with 10 eyes improved, 6 eyes stable and 9 eyes detoriated. Looking at the size of the CNV being treated 8 from 10 eyes with improved vision had a CNV size less than 1/4 disc diameter ( DD ), whereas in the group with visual detoriation there was none with a CNV less than 1/4 DD.
Conclusion: In a short history of visual detoriation, with a relatively good visual acuity and especially an CNV size less than 1/4 DD, radiotherapy is still a treatment to be considered in AMD.
1Augenklinik und 2Klinik für Strahlentherapie und Radio-Onkologie,
Klinikum Wuppertal GmbH, Klinikum der Universität Witten-Herdecke, Akademisches Lehrkrankenhaus der Heinrich-Heine-Universität Düsseldorf