97th DOG Annual Meeting 1999



A. W. A. Weinberger, L. Najjari, C. Dahlke, T. Kube, S. Wolf

Background: The multifocal ERG (mf-ERG) allows a diffentiated topographical analysis of macular responses. In disease like AMD and macular hole a circumscribed or focal reduction of amplitudes in the mf-ERG could be observed. In this study we evaluated changes in the mf-ERG in patients with retinal central- (CRVO) or branch vein occlusion (BRVO).

Methods: In this study 12 patients with CRVO and 10 patients with BRVO were included. The mf-ERG's recorded and compared to the fellow eye (CRVO or the non- affected hemisphere of the affected eye (BRVO). Minimal visual acuity for inclusion was 20/200. For stimulation and mf-ERG recording a system from Roland Consult (Wiesbaden) was used. Stimulation was conducted with a VGA-monitor with 61 fields and in a 24º field of view. Statistical analysis was performed using the Mann-Whitney-non-parametrical test (significance for p<0,05).

Results: Patients with CRVO showed a significant reduction of the b-amplitude means of sum potentials compared to their normal fellow eyes (p = 0.02). In BRVO patients the b-amplitude means of sum potentials in the affected retinal hemisphere were also significantly reduced (p = 0,042)

Conclusion: The analysis of mf-ERG's in patients with retinal vein occlusion shows reduced mean b-amplitudes in affected eyes or retinal hemispheres. In some cases with BRVO the differences were surprisingly small for the clinical appearance and visual acuity. We believe that a lack of fixation due to foveal involvement in these cases contributes to these results. Fixation control and correction will increase the value of this new diagnostic tool.

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