97th DOG Annual Meeting 1999
REMOVAL OF PERFLUOROCARBON LIQUIDS FROM THE RETINA -
A COMPARITATIVE STUDY
C. Esken1, M. Winter1, C. Winter2
Perflourocarbon liquids (PFCL) are used during complicated vitreoretinal surgery for stabilization and reattachment of detached retinae. Even after macroscopic complete removal occasionally small droplets of applied PFCL can be observed postoperative by indirect ophthalmoscopy. Purpose of this study was to determine differences in the quantities of retained perfluorodecalin (PFD), perfluorooctane (PFO) or perfluoroperhydro-phen-anthrene (PFP) on the retina.
Methods: Fresh enucleated eyes from pigs without anterior segment and vitreous were filled with PFD, PFO or PFP. In a first experiment these PFCL were macroscopically completely aspirated under Ringers solution. In a second experiment a fluid-air exchange was simulated and PFCL removed under air. Then on the retina retained portions of PFCL were solved in a wash-out fluid (perfluoromethylcyclohexane) and quantified by gas-chromatography.
Results: Even after macroscopic complete removal PFCL were detected in all probes. In exchange with Ringers solution the portion of retained PFCL was smaller than with air. PFO was removed best.
Conclusion: With aspiration alone the investigated PFCL were not completely removable from the retina. PFO can be removed better then PFD and PFP. This may be due to the high surface tension and the low viscosity of PFO.
1Department of Ophthalmology, Christian-Albrechts-Universität of Kiel,
Hegewischstr. 2, D-24105 Kiel
2Pharmaceutical Institute, Christian-Albrechts-Universität of Kiel
Gutenbergstr. 76-78, D-24118 Kiel
Project of the "Arbeitsgemeinschaft für Glaskörperersatz"