97th DOG Annual Meeting 1999
EFFICIACY OF TIMOLOL HYDROGEL 0.1% IN PATIENTS WITH OPEN ANGLE GLAUCOMA
N. Ardjomand, B. Feigl, M. Eckhardt
Purpose: Timolol hydrogel 0.1% (carbomerbased hydrogel with timolol maleate) is known to reduce the intraocular eye pressure (IOP). The effect of Timolol hydrogel 0.1% and its use comfort in patients with open angle glaukoma was evaluated.
Material and methods: 21 patients (37 eyes) were given Timolol hydrogel 0.1% either as the first antiglaucomatous therapy (group 1: 18 eyes) or in cases of eye burning under treatment with Timolol 0.5% (group 2: 19 eyes). The patients used the drops once a day in the morning and were followed up for 3 months. The Wilcoxon signed rank test was used to investigate the statistical significance.
Results: In group 1 the IOP reduction was 31% (± 3%) after 1 week (p<0.001), 25% (± 3%) after 3 weeks (p<0.001) and 34% (±2%) after 3 months (p<0.005). In group 2 the IOP reduction was 15% (± 2%) after 1 week (p<0.0001), 10% (± 3%) after 3 weeks (p<0.02) and 15% (± 3%) after 3 months (p<0.03). All patients reported blurred vision for a few minutes after using Timolol hydrogel 0.1%, but few to no eye burning compared with the aqueous Timolol 0.5%.
Conclusion: Timolol hydrogel 0.1% reduces the IOP of up to 34% after 3 months. The main advantages of this new carbomerbased hydrogel of Timolol are its once-a-day use and, its low concentration of 0.1%, and improved ocular comfort.
Department of Ophthalmology, Karl - Franzens - University, Auenbruggerplatz 4, A-8036 Graz