97th DOG Annual Meeting 1999

P386

TTGFß2 VALUES IN THE AQUEOUS HUMOR IN DIFFERENT TYPES OF GLAUCOMA AND THE RELATION TO FILTERING BLEB DEVELOPMENT

Picht G.1, Welge-Lüssen U.2, Grehn F.1, Lütjen-Drecoll E.2


Introduction: Transforming growth factor type beta (TGFß2) is a multifunctional component of aqueous humor. TGFß2 is discussed to play a role in the scarring process of filtering blebs.

Methods: Aqueous humor of 55 glaucoma eyes (29 eyes with primary open angle glaucoma (POAG), 17 eyes with pseudoexfoliative glaucoma (PSX), 9 eyes with juvenile glaucoma (JG)) was collected at the beginning of filtering surgery. Aqueous humor from 29 eyes with cataract was collected as control group. TGFß2-values and protein concentration were determined. The postoperative follow-up (intraocular pressure, filtering bleb development, further interventions) and preoperative clinical data (age, gender, intraocular pressure, previous treatment) were correlated to the TGFß2-values.

Results: TGFß2-values of POAG-eyes (64-444 pg/ml, mean 213,7 pg/ml) and JG-eyes (21-582 pg/ml, mean 253,3 pg/ml) were higher than in the control group (66-197 pg/ml, mean 127,4 pg/ml), in contrast to PSX-eyes with normal TGFß2-values (45-134 pg/ml, 1 eye 332 pg/ml, mean 122,5 pg/ml). Correlation between TGFß2-values and the postoperative follow-up of POAG eyes revealed that eyes with good clinical outcome had normal TGFß2-values. From the eyes with unfavourable outcome, 9 eyes had elevated and 5 eyes had normal TGFß2-values. There was no correlation between preoperative clinical data and TGFß2-values.

Conclusion:
1. The fact that POAG-eyes with favourable bleb development have normal TGFß2-values may indicate some relationship between TGFß2-levels and bleb formation.
2. Various types of glaucoma differ not only by their biomicroscopial appearance, but also by their TGFß2-levels of the aqueous humor.

1 Universitäts-Augenklinik Würzburg,
2 Anatomisches Institut, Lehrstuhl II, Erlangen-Nürnberg


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