97th DOG Annual Meeting 1999



V. Seiberth 1,2, R. Degenring2, I. Akkoyun2, W. Jendritza2, C. Vögele2, H. Schmitt3

An elevated level of plasma prorenin (PP) in patients with diabetes mellitus may be associated with proliferative diabetic retinopathy. Although retinopathy of prematurity (ROP) is characterized as well as diabetic retinopathy by retinal vasoproliferation, there is no study on PP and ROP. The aim of the present study is to show a possible correlation of ROP and PP.

Methods: In 331 preterm infants (gestational age 24 - 36 weeks, mean + SD 29.6 ± 2.7 weeks; birth weight 570 - 1750 g, 1161 ± 297 g) PP was examined prospectively in 476 blood samples taken between 3 and 11 weeks postnatally. Renin and after cryo activation total renin were assessed by radio immuno assay. Total renin minus renin shows the PP level. PP was correlated with the presence of ROP, the stage of ROP, gestational age, birth weight and postnatal age.

Results: Mean PP in 142 preterm infants with ROP (663 ± 499 ng/l) did not show any significant difference when compared to mean PP in 189 preterm infants without ROP (723 ± 667 ng/l) (P = 0.272). There was no correlation between PP and the stage of ROP, the gestational age or birth weight. With increasing postnatal age mean PP decreased during the study period (postnatal age 3 - 5 weeks: 994 ± 699 ng/l; 6 - 8 weeks: 801 ± 578 ng/l; 9 - 11 weeks: 548 ± 535 ng/l).

Conclusion: This study does not reveal any significant difference in PP in preterm infants with and without ROP. PP is not of any value in the diagnostic of ROP. However, the study shows a correlation between PP and postnatal age of preterm infants which is unknown to date.

1 Klinik für Augenheilkunde, Marienhospital, D-49074 Osnabrück
2 Universitäts-Augenklinik, Klinikum Mannheim, D-68135 Mannheim
3 Institut für Klinische Chemie, Klinikum Mannheim, D-68135 Mannheim