97th DOG Annual Meeting 1999
FLUORESCEIN-ERG: A SENSITIVE METHOD FOR THE DETECTION OF FUNCTIONAL ABNORMALITIES CAUSED BY RETINAL VASCULAR DAMAGE.
M. Janaky, A. S. Boros, T. Peto, G. Benedek*, L. Kolozsvari
Purpose: The reintroduction of simultaneously performed fluorescein angiography and ERG in the early detection of retinal functional abnormalities.
Methods: 13 patients suffering from type 1 diabetes mellitus, 7 patients with central retinal vein thrombosis on the fellow eye, 5 patients with pigment epithelial abnormalities of vascular origin, and 7 patients with inherited familial retinitis pigmentosa were examined. ERGs were recorded with gold-foil electrodes to blue flash before fluorescein angiography, immediately after it and 15, 30, 45 and 60 minutes thereafter.
Results: Administration of fluorescein caused a slight increase in the ERG of healthy individuals. Considerable amplitude enhancement was recorded, however, in diabetic patients in the non-thrombotic eye of patients with central retinal vein occlusion and in patients with pigment epithelial abnormalities caused by retinal vascular disorders. In inherited retinitis pigmentosa cases, however, fluorescein-ERG showd no alterations at all during the recording period.
Conclusions: Our results prove the high sensitivity of fluorescein-ERG method in the detection of vascular and functional abnormalities of the retina. The method seems to have the advantage over fluorophotometry that it reveals not only pathologies of retinal vessels but the abnormal sensitivity of retinal sensory elements, too.
Department of Ophthalmology and Physiology*, Albert Szent-Gyorgyi Medical University, Szeged, Hungary