97th DOG Annual Meeting 1999
BACTERIAL KERATITIS UNDER SYSTEMIC TREATMENT WITH AZATHIOPRINE
N. Ardjomand, W. Salmhofer, P. Komericki, M. Eckhardt
Background: Different medical treatment modalities are available for the treatment of autoimmune disease. Azathioprine is known to increase the incidence of bacterial infections compared with other immunosuppressive drugs.
Patients and Methods: Two patients with pemphigus foliaceus and systemic immunosuppression (corticosteroids in combination with azathioprine) developed a monocular bacterial keratitis. In one case (patient 1) treatment with azathioprine could not be stopped from dermatological site und underwent topical antibiotical treatment. In the second case (patient 2) treatment with azathioprine was stopped and topical antibiotical treatment was given.
Results: It took 8 weeks until the corneal ulcer was closed in patient 1. Patient 2 had a sterile corneal ulcer after 1 week and the ulcer was closed after 3 weeks.
Conclusion: Immunosuppressive therapy with azathioprine prologs the healing process of ocular bacterial infections and should be stopped in cases of keratitis.
Department of Ophthalmology, Auenbruggerplatz 4, A - 8036 Graz