97th DOG Annual Meeting 1999
PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING AFTER EXTRACAPSULAR CATARACT EXTRACTION UNDER GENERAL ANESTHESIA
H. Gäckle1, L. H. J. Eberhart2, G. K. Lang1
Background: Postoperative nausea and vomiting after eye surgery occurs frequently and can lead to serious complications in the early postoperative period. Droperidol (Dro) and 5-HT3-antagonists such as dolasetron (Dol) are potent antiemetics and are often used alone or in combination to prevent postoperative nausea and vomiting (PONV).
Methods: In this randomised double-blind study 141 patients under-going extracapsular cataract extraction under general anaesthesia were included. Standardised anaesthesia was performed on all patients. Ten minutes before the end of surgery patients received saline (n=35), Dro 10 µg.kg-1 (n=35), Dol 12.5mg (n=36) or a combination of Dro 10 µg.kg-1 and Dol 12.5mg (n=35) i.v.. One, 2, 5, 8 and 24 hours postoperatively, the patients were investigated for the occurrence and severity of nausea, retching, and vomiting. PONV was rated as none, mild, moderate and severe using a standardised scoring algorithm. The x2-test was used for statistical analysis. A p-value of 5% was considered as statistically significant.
Results: More patients stayed complete free from nausea and vomiting in all three treatment groups compared to placebo (p<0.05). However, there was no difference between Dro and Dol, nor between the combination.
Conclusion: Droperidol and dolasetron are effective antiemetic drugs and both reduce the incidence of PONV to a satisfying level after cataract surgery. A combination of the drugs does not improve efficacy of the treatment.
Department of Ophthalmology 1 and Anaesthesiology 2,
University of Ulm, Germany Prittwitzstrasse 43, D-89075 Ulm, Germany